OUR INNOVATIVE AND PATENTED TECHNOLOGY
GeniPhys technology comprises standardized collagen polymer building blocks or Collymers that exhibit self-assembly (solution to matrix transition) and support hierarchical engineering design of collagen-fibril materials that guide cell fate and support formation of complex tissues and organs in vitro and in vivo. These technologies were inspired by new insights into how fibrillar type I collagen is synthesized and assembled within the body to give rise to the extracellular matrix (ECM) and associated tissue- and organ-specific form and function. This platform supports cell encapsulation and user specification of the following hierarchical tissue design parameters: molecular composition (including collagen intermolecular crosslinks), fibril microstructure (fibril density, interfibril branching, porosity, and homogenous and gradient architectures), matrix biophysical properties (stiffness, solute/fluid transport, and proteolytic degradability), and macro-level geometry and format. Since this technology recapitulates the natural fibrous structure of the ECM and its associated mechanobiology signaling, in-vitro tissue systems more accurately predict in-vivo human responses and implantable materials foster tissue integration and regeneration rather than the default foreign body response (fibrosis) observed with conventional synthetic and metal implants.